People with chronic heart failure—and there are millions in this country—may be prescribed multiple medications to manage their disease. However, a study at the University of Michigan suggests those hospitalized or seeking emergency treatment were sometimes lacking in one or more of the medications. Clinical studies offer a simple solution—a polypill for heart failure. The polypill combines four common medications to treat low ejection fraction of the heart. Although still in clinical trials, researchers found patients on the polypill had a sixty percent lower rate of hospitalizations related to heart failure. They also showed the combination of medications reduced heart failure deaths by fifty percent compared to patients on a conventional two-drug treatment. Details in the journal Nature Medicine.