Aging is driven by multiple biological markers and excess body weight appears to promote many of those changes, suggesting that obesity acts as an accelerator of biological aging. Authors of the review in the journal Genes and Diseases say they observed that one of the strongest links between obesity and aging is chronic low-grade inflammation. They also looked at whether anti-aging treatments could help slow down aging and reduce age-related diseases. Lifestyle changes, such as calorie restriction and exercise, have been associated with improvements in metabolic functions linked to aging along with modern anti-obesity medications for their role in possibly improving healthy lifespan.